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This course is designed to train advanced graduate students,
post-docs, and independent investigators in different molecular methods
used to study human fungal pathogens, and the models at the forefront
of research to uncover the mechanisms that underlie fungal diseases and
their treatment. Limited to 18 students.
Training is provided through
laboratory
exercises and demonstrations, lectures by resident faculty and visiting
seminar
speakers, and informal panel discussions. Laboratory exercises focus
primarily
on Candida, Aspergillus, and Cryptococcus, and focus on
different
areas such as genetic manipulation of fungi, cell culture and in vivo
pathogenicity and host response assays, genomic analyses, assessment of
genome
instability, antifungal resistance assays, and the microscopic analysis
of
fungi. Students are presented with the current views of
pathogenesis of different
key human fungal pathogens and the approaches used to study these
fungi. In
order to broaden students understanding of the field, invited
seminar
speakers
provide further
insight into Candida, Aspergillus, Cryptococcus biology
and
present
work on other fungi such as Histoplasma,
Coccidioides, and Pneumocystis. Specialized lectures
in areas relating to drug discovery, molecular diagnostic techniques,
virulence, genome structure and evolution, mating, vaccine strategies,
and host defenses are also included. Panel discussions focus on issues
in medical mycology, development of new research techniques and
paradigms, and topics relating to professional development within the
field of fungal pathogenesis.
This course is supported with funds provided by
Burroughs
Wellcome Fund
Howard
Hughes Medical Institute
2012 Faculty and Lecturers:
Gordon Brown, Aberdeen University, U.K.
Tamara Doering, Washington University Medical School
Jack Edwards, UCLA-Harbor
Scott Filler, UCLA School of Medicine
Amy Gladfelter, Dartmouth College
Joseph Heitman, Duke University
Bernard Hube, ILRS Jena
Ashraf Ibrahim, UCLA School of Medicine
James B. Konopka, SUNY Stony Brook
Aaron Mitchell, Carnegie Mellon University
Eleftherios Mylonakis, Massachusetts General Hospital
Carol Munro, Aberdeen University, U.K.
Andre Nantel, Biotechnology Research Institute, NRC
Donald C. Sheppard, McGill University
Anita Sil, University of California, San Francisco
Jason Stajich, University of California, Riverside
Robert Wheeler, University of Maine Orono
Theodore C. White, University of Missouri, Kansas City
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