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An intensive six-week laboratory and lecture course for advanced
graduate students, postdoctoral fellows, and more senior researchers
who seek a broad and balanced view of the modern issues of
developmental biology. Limited to 24 students.
The integrated lectures and laboratories provide a comprehensive
coverage of the paradigms, problems, and technologies of modern
developmental biology, cast within a framework of metazoan evolution.
Students are exposed to a wide variety of embryonic systems, including
intensively studied genetic model systems ( e.g. C. elegans
, Drosophila , zebrafish mouse) and
others with well-established experimental attributes ( e.g.
chick, sea urchins, frogs, ascidians). In addition,
students will be introduced to a wide range of emerging systems,
including locally available marine organisms, that help fill in the
evolutionary history of animal diversity ( e.g. cnidarians,
nemerteans, planaria, crustaceans, mollusks, and annelids) and that are
becoming established as experimental systems in their own right. This
broad coverage of metazoan phylogeny allows for the analyses of the
developmental strategies that drive evolutionary change. Analytical and
experimental techniques used to explore invertebrate and vertebrate
development include embryological manipulation (e.g. cell ablation,
tissue grafting), molecular genetic ( e.g. RNAi,
electroporation) and cell biology approaches ( e.g. analysis
of cell lineage and migratory behaviour), and microscopic and imaging
technologies (e.g. confocal and 3-D time lapse), using state-of-the-art
instrumentation and methodology. Conceptual topics include cell
specification and differentiation, pattern formation, embryonic axis
formation, morphogenesis, intercellular signaling, transcriptional
regulation, organogenesis, and modern comparative embryology.
2012 Faculty:
Baker, Clare, University of Cambridge
Bronner, Marianne, California Institute of Technology
Collazo, Andres, House Ear Institute
Fitch, David, New York University
Harland, Richard, University of California, Berkeley
Henry, Jonathan, University of Illinois
Keller, Raymond, University of Virginia
Maddox, Amy, University of Montreal
Maddox, Paul, University of Montreal
Martindale, Mark, University of Hawaii
McClay, David, Duke University
Ober, Elke, National Institute for Medical Research
Patel, Nipam, University of California, Berkeley
Piotrowski, Tatjana, Stowers Institute for Medical Research
Ronshaugen, Matthew, University of Manchester
Rothman, Joel, University of California, Santa Barbara
Seaver, Elaine, University of Hawaii
Sherwood, David, Duke University
Smith, Joel, MBL
Trainor, Paul, Stowers Institute for Medical Research
Wikramanayake, Athula, University of Miami
Zeller, Robert, San Diego State University
This course is supported with funds provided by:
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