 |
|
|
|
|
|
|
|
|
|
|
 |
|
An intensive six-week course consisting of
lectures and laboratories. This course is limited to 20 participants
and is designed for postdoctoral and clinical fellows, newly
independent scientists and physicians, or senior graduate students who
are seeking training in state-of-the art research strategies and
methods needed to pursue studies on reproductive sciences.
The course is divided into three major sections of two weeks' duration.
Each section consists of lectures from resident faculty and other
invited speakers, discussions and informal seminars, laboratory
exercises, demonstrations, and one-on-one tutorials.
The first section covers signal transduction and gene expression in reproductive endocrinology and is directed by Lane Christenson. The laboratories of this section are devoted to the study of (a) the signaling pathways activated by the gonadotropin receptors in their target cells; (b) the mode of action of the classical steroid receptors; (c) transcriptional and post-transcriptional regulation of gene expression; and (d) the use of bioinformatics tools for mining public databases.
The second section covers embryology and implantation biology,
cell-cell interactions in reproductive tissues during development as
well as transgenic technology. This section is directed by Ann
Sutherland and consists of lectures and laboratories on implantation,
decidualization, angiogenesis, placental immunology, reproductive tract
development, and sex differentiation, as well as transgenic techniques
and their use in determining the consequences of specific gene ablation
on embryo implantation. Techniques emphasized in this section include
artificial decidualization, invasion assays, flow cytometry, laser
capture microdissection, oocyte and embryo microinjection, manual
dissection of embryos at various stages of development, tissue
recombinations, and organ culture.
The third section, directed by Harvey Florman, is focused on
gametogenesis, fertilization, cloning, and stem cells. This section
consists of laboratories on (a) the culture, maturation and analysis of
ovarian follicles and mouse oocytes; (b) the transplantation of germ
cells; (c) the analysis of meiotic cell cycle control using living and
fi xed germ cells (d) ICSI, cloning, and preimplantation genetic
diagnosis; (e) assisted reproductive technologies; and (f) embryonic
stem cells, nuclear transfer, and cloning. Experiments rely heavily on
the use of various imaging strategies to explore dynamic aspects of
germ cell and embryo behaviors such as cell-cell interactions,
signaling, chromatin remodeling, and differences between meiotic and
mitotic cell cycle progression.
In each of the sections the laboratory exercises are supplemented with
lectures by resident faculty and other leading investigators who
discuss their current research in various aspects of reproduction
ranging from gamete interactions, early development, implantation,
parturition, immunology, the molecular and cellular basis of hormone
action in reproductive tissues, reproductive disorders and clinical
aspects of reproductive biology and endocrinology. Resident faculty
also lead discussions on the theoretical basis of the laboratory
exercises as well as discussions of the expected outcomes and the
potential clinical relevance of some of the areas of focus.
The course also includes discussions on professional development such
as publishing, funding opportunities, and grant preparation and review.
Frontiers in Reproduction ends with a two-day symposium featuring
seminars by distinguished speakers and short research presentations by
current and previous participants.
This course is supported with funds provided by
Burroughs Wellcome Fund
National
Institute
of Child Health and Human Development, NIH
World
Health Organization
American
Society for Reproductive Medicine
Substantial financial aid is available to admitted applicants
regardless of nationality. Scholarships are based on need and may cover
the majority of course and travel costs.
2011 Faculty and Lecturers:
David Albertini, University
of
Kansas
Medical Center
Russell Broaddus, MD Anderson
Cancer Center
Jackson Brown, University of
Birmingham
Sally Camper, University of Michigan
Paula Cohen, Cornell University
Marco Conti, University of California, San Francisco
Paul Cooke, University of Illinois
Francesco DeMayo, Baylor College of
Medicine
Ina Dobrinski, University of Calgary
Tanja Dominko, Worcester Polytechnic Institute
Asgi Fazleabas, Michigan State University
Rafael Fissore, University of
Massachusetts
Louis Guillette, University
of
Florida
Stephen Hammes, University of
Rochester Medical Center
Mary Ann Handel, The Jackson Laboratory
Barry Hinton, University of Virginia School of Medicine
Laurinda Jaffe, University of Connecticut Health
Center
Greg Johnson, Texas
A&M University
Ursula Kaiser, Brigham and Women's Hospital
Ruth Keri, Case Western Reserve University
Kenneth Korach, NIEHS/NIH
Carol Lange, University of Minnesota
Jon Levine, Northwestern University
Martin Matzuk, Baylor College of
Medicine
Michael McClure, Environmental
Protection Agency
Eric Overstrom, Worcester Polytechnic
Institute
Ray Page, Worcester Polytechnic
Institute
Margaret Petroff, University of Kansas
Medical Center
Oliver Rando, University of
Massachusetts Medical School
Prabhakara Reddi, University of Virginia
Dale Redmer, North Dakota State
University
Renee Reijo Pera, Stanford University
Lawrence Reynolds, North Dakota State
University
Gerald Schatten, Pittsburgh
Development Center
Richard Schultz, University of Pennsylvania
Stephanie Seminara, Massachusetts
General
Hospital
Paula Stein, University of Pennsylvania
Keith Sutton, University of Massachusetts Medical
School
Sergei Tevosian, Dartmouth College
Victor Vacquier, University of
California, San Diego
Humphrey Yao, University of Illinois
|
| |
|
|
|
|
>
|
