| Wednesday, August 20 |
| 8:15 - 8:30 |
Introductions |
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| 8:30 - 9:15 |
Thomas A. Rando, M.D., Ph.D.
Palo Alto Institute for Research and Education, Inc. & Stanford University
Mechanisms of Rejuvenation of Tissue-specific Stem Cells |
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| 9:15 - 10:00 |
James L. Sherley, M.D., Ph.D.
Boston Biomedical Research Institute
A New Molecular Hypothesis for Aging: Chemical Change in Immortal DNA Strands in Distributed Stem Cells |
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| 10:00 - 10:30 |
Break |
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| 10:30 - 11:15 |
Carlos Lois, M.D., Ph.D.
Massachusetts Institute Technology
The Role of Adult Neurogenesis in the Brain of Adult Songbirds: A Transgenic Approach |
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| 11:15 - 12:00 |
Michael H. Brodsky, Ph.D.
University of Massachusetts Medical School
Epigenetic Regulation of Drosophila Telomere Protection |
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| 12:00 - 1:00 |
Lunch |
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| 1:00 - 1:45 |
Estela Medrano, Ph.D.
Baylor College of Medicine
Epigenetic Control of Senescence and Aging |
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| 1:45 - 2:30 |
Su-Ju Lin, Ph.D.
University of California, Davis
Molecular Mechanisms of Calorie Restriction and Longevity Regulation - Insight from Budding Yeast |
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| 2:30 - 3:15 |
Marc Tatar, Ph.D.
Brown University
Metabolomic Analysis of Drosophila Aging by Stable Isotope Spectrometry |
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| Thursday, August 21 |
| 8:00 - 8:45 |
Scott Pletcher, Ph.D.
Baylor College of Medicine
The Role of Innate Immunity Signaling in Lifespan Extension via Dietary Restriction in Drosophila melanogaster |
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| 8:45 - 9:30 |
Beverly Paigen, Ph.D.
The Jackson Laboratory
Longevity and the IGF1 Pathway: Analysis of 31 Inbred Mouse Strains from the Jackson Lab Mouse Phenome Project |
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| 9:30 - 10:15 |
Alfred L. Goldberg, Ph.D.
Harvard Medical School
Regulation of Protein Degradation by the Ubiquitin-Proteasome Pathway in Aging |
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| 10:15 - 10:45 |
Break |
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| 10:45 - 11:30 |
Alexander Varshavsky, Ph.D.
California Institute of Technology
Lifespan Extension: Overexpression Strategies in the Mouse and Yeast content =ubiquitin system |
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| 11:30 - 12:15 |
Xiaohua Wu, Ph.D.
The Scripps Research Institute
The role of the Mre11/Rad50/Nbs1 complex in S-phase checkpoint control and DNA double-strand break repair |
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| 12:15 - 1:15 |
Lunch |
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| 1:15 - 2:00 |
H. Robert Horvitz, Ph.D.
Massachusetts Institute of Technology
Genetic Control of Aging in C. elegans |
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| 2:00 - 2:45 |
Monica Driscoll, Ph.D.
Rutgers University
Genetic Analyses of Extended Healthspan in C. elegans |
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| 2:45 - 3:30 |
Heidi Scrable, Ph.D.
University of Virginia
Genetic Models to Chart the Course of Aging in the Mouse |
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| Friday, August 22 |
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| 8:00 - 8:45 |
Catherine A. Wolkow, Ph.D.
National Institute on Aging
Tracing Pathways for Controlling Longevity by Insulin-like Signaling in the Nervous System |
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| 8:45 - 9:30 |
Andrew G. Dillin, Ph.D.
The Salk Institute for Biological Studies
Aging, Metabolism, and Neurodegeneration |
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| 9:30 - 10:00 |
Break |
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| 10:00 - 10:45 |
Robert D. Goldman, Ph.D.
Northwestern University
Lamin A Mutations in Progeria: Changes in Nuclear Structure and Function |
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| 10:45 - 11:30 |
Jaime Grutzendler, M.D.
Northwestern University
Neuroprotective roles of microglia in Alzheimer’s disease |
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| 11:30 - 12:30 |
Lunch |
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| 12:30 - 1:15 |
Harry B. Gray, Ph.D.
California Institute of Technology
Conformational Dynamics of Alzheimer’s and Parkinson’s Polypeptides |
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| 1:15 - 2:00 |
Susan L. Lindquist, Ph.D.
Whitehead Institute for Biomedical Research
Investigating the Potential Involvement of Cellular Quality Control Mechanisms and the Mammalian Prion, PrP, in Neurodegenerative Diseases |
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| 2:00 - 2:45 |
Pere Puigserver, Ph.D.
Dana Farber Cancer Institute
Regulation of Glucose Homeostasis through PGC-1_ and SIR2_ |
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| 8:00 PM |
1st Annual Joshua Lederberg Lecture
Gary Ruvkun, Ph.D.
Harvard Medical School
Universal Genetic Programs of Animal Longevity
Presentation of Lecture Award to Marguerite Lederberg
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